Phenibut Supplement Facts & Information
Phenibut Supplement Guide:
What is it and where does it come from?
Phenibut is derived from the neurotransmitter GABA.1 GABA is a neurotransmitter responsible for nerve signal transmission efficiency, and elevated GABA levels are necessary for sound sleep.
What does it do and what scientific studies give evidence to support this?
Phenibut (beta-phenyl-gamma-aminobutyric acid) has a long history of clinical use in Russia.
Who needs it and what are some symptoms of deficiency?
All persons can benefit from phenibut supplementation due to its ability to induce relaxation and improve mental function. Phenibut supplementation may be especially efficacious for athletes and people living hectic, stress filled lifestyles.
No symptoms of deficiency exist.
How much should be taken? Are there any side effects?
Strictly adhere to label recommendations.
Tolerance is a side effect of chronic administration. Tolerance is a phenomenon whereby the body either:
1. Down regulates the endogenous production of a substance in response to elevated levels arising from exogenous introductions.
2. Reduces the affinity of its receptor sites to a ligand of exogenous origin
With respect to the chronic administration of phenibut, the body down regulates the affinity of its receptors to phenibut. This will result in a decrease of phenibuts efficiency over time. This will require increasingly larger doses to be administered to maintain the original effects seen with the first dosage.
The toxicity of phenibut is very low. No reports of overdose have been reported when used in moderation, and no reports of dependency have emerged in scientific literature.
Persons on MAOI inhibitors or epilepsy medications like tegretol or trileptal should consult with their psychiatrist / physician prior to supplementation with phenibut. Clinical research has demonstrated that phenibut can potentate or inhibit the function of some epilepsy medications.
1. Pavlov J Biol Sci. 1986 Oct-Dec;21(4):129-40. On neurotransmitter mechanisms of reinforcement and internal inhibition. Shulgina GI.
2. Arch Immunol Ther Exp (Warsz). 1975;23(6):733-46. Pharmacological properties of gamma-animobutyric acid and it derivatives. IV. Aryl gaba derivatives and their respective lactams. Chojnacka-Wojcik E, Hano J, Sieroslawska J, Sypniewska M.
Republished from Clayton South's Health Facts.
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